A diverse pipeline of topical skin medications
EPSOLAY®
(encapsulated benzoyl peroxide) Cream, 5%
Papulopustular Rosacea
NDA Submission Q2 2020
TWYNEO®
(encapsulated benzoyl peroxide and encapsulated tretinoin) Cream 3%/0.1%
Acne Vulgaris
NDA Submission 2H 2020
SGT-210
Palmoplantar Keratoderma
Results in 1H/2021
tapinarof
Psoriasis & Other Dermatological Indications
Formulation
roflumilast
Psoriasis & Other Dermatological Indications
Formulation
The safety and efficacy of these products have not been established.
Novel Drug Delivery Technology
EPSOLAY
Epsolay is an investigational topical cream containing encapsulated benzoyl peroxide, 5%, for the treatment of papulopustular rosacea. Epsolay utilizes a patented technology process that is designed to slowly release benzoyl peroxide over time to the skin. If approved, Epsolay has the potential to be the first single-active benzoyl peroxide approved by the FDA as a prescription drug product.
The safety and efficacy of Epsolay have not been established.
Epsolay is a registered trademark of Sol-Gel Technologies, Ltd.
Not an actual patient – actor portrayal
Not an actual patient – actor portrayal
EPSOLAY
Epsolay is an investigational topical cream containing encapsulated benzoyl peroxide, 5%, for the treatment of papulopustular rosacea. Epsolay utilizes a patented technology process that is designed to slowly release benzoyl peroxide over time to the skin. If approved, Epsolay has the potential to be the first single-active benzoyl peroxide approved by the FDA as a prescription drug product.
The safety and efficacy of Epsolay have not been established. Epsolay is a registered trademark of Sol-Gel Technologies, Ltd.
Not an actual patient – actor portrayal
TWYNEO
Twyneo is an investigational, antibiotic-free, fixed-dose combination of benzoyl peroxide, 3%, and tretinoin, 0.1%, cream for the treatment of acne vulgaris, using our proprietary drug-delivery technology. If approved, it has the potential to be the first acne treatment on the market that contains a fixed-dose combination of benzoyl peroxide and tretinoin. Tretinoin and benzoyl peroxide are each approved as single-agent products for the treatment of acne. They are frequently prescribed together, however, they have not yet been marketed as a combination product because benzoyl peroxide causes degradation of tretinoin when combined in the same formulation. In Twyneo, each ingredient is encapsulated in a silica shell, which is designed to release the ingredients slowly over time. Phase 3 studies are complete and we plan to submit our New Drug Application in 2H2020.
The safety and efficacy of Twyneo have not been established. Twyneo is a registered trademark of Sol-Gel Technologies, Ltd.
TWYNEO
Twyneo is an investigational, antibiotic-free, fixed-dose combination of benzoyl peroxide, 3%, and tretinoin, 0.1%, cream for the treatment of acne vulgaris, using our proprietary drug-delivery technology. If approved, it has the potential to be the first acne treatment on the market that contains a fixed-dose combination of benzoyl peroxide and tretinoin. Tretinoin and benzoyl peroxide are each approved as single-agent products for the treatment of acne. They are frequently prescribed together, however, they have not yet been marketed as a combination product because benzoyl peroxide causes degradation of tretinoin when combined in the same formulation. In Twyneo, each ingredient is encapsulated in a silica shell, which is designed to release the ingredients slowly over time. Phase 3 studies are complete and we plan to submit our New Drug Application in 2H2020.
The safety and efficacy of Twyneo have not been established.
Twyneo is a registered trademark of Sol-Gel Technologies, Ltd.
Not an actual patient – actor portrayal
SGT-210
SGT-210 is an investigational, topical epidermal growth factor receptor inhibitor in development for the treatment of palmoplantar keratoderma (PPK), a group of skin conditions characterized by thickening of the skin on the hands and soles of the feet, as well as basal cell carcinoma and squamous cell carcinoma, collectively referred to as non-melanoma skin cancer.
tapinarof and roflumilast
We also intend to develop tapinarof, an aryl hydrocarbon receptor (AhR) agonist, and roflumilast, a phosphodiesterase 4 (PDE4) inhibitor, each as potential treatments for psoriasis and other dermatological indications.
The safety and efficacy of SGT-210, tapinarof, and roflumilast have not been established.